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KMID : 0378019860290050015
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New Medical Journal
1986 Volume.29 No. 5 p.15 ~ p.22
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Action mechanism of capsici fructus on pumping enzymes in the membrane of gastrointestinal cell
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SON SUN-K.
KOH IL-S.
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Abstract
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The effects of capsici fructus on Ca ATPase and NaK ATPase were investgated in the red cell membrane. The Ca ATPase activity was inhibited by capsici fructus but the NaK ATPase activity was stimulated in the cell membrane. Since the Ca ATPase is intimately associated with the Ca pump; therefore, the Ca pump rate is inhibited by capsici fructus in cell membrane. The inhibitory effect of capsici fructus on Ca ATPase activity is dependent on the Na concentration. Thereby, in the presence of capsici fructus, the Ca ATPase activity is inhibited ; 8.3% at Na concentration of :50mM. Since the intracellular Na} concentration is 5ⓒmM in intestinal cell (Schltz and Curran, 1968), therefore, inhibition of Ca pumping rate is more marked in the gastric muscle membrane by capsici fructus. Since the Ca pumping rate in muscle membrane is directly dependent on the contractile activity of muscle (Weber et al., 1963), the Ca pump is inhibited by capsici fructus at high rate in gastric muscle membrane which initiates mucular contraction. It can be reasonably .assumed that the Ca pumping rate is inhibited by capsici fructus at the gastric muscle membrane ,continually which change to cause swelling of cell volume. This swelling cell is known as cancer cell. On the other hand, since the NaK ATPase is intimately linked to the Na pump, therefore, the Na pumping rate is stimulated by capsici fructus. The Na pumping rate is stimula ed by capsici fructus at low rate in intestin 1 cell membrane which change to increases per stalsis of gastrointestinal tract and inhibts the abs rption of water, and then to cause diarrhea.
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KEYWORD
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